Endocrine Abstracts

Hypothyroidism presents diagnostic challenges when occurring in an extremely unwell infant with hepatoblastoma. This case indicates a possible link between Beckwith–Wiedemann syndrome (BWS) and severe hypothyroidism.Antenatally, the baby had polyhydramnios and an abdominal mass. After normal vaginal delivery at 38+4 weeks, examination showed macrosomia (4007 g) small nose, low set ears and inverted V-shaped mouth. Transient hypoglycaemia on day 1 re...

Background: Reduced bone mineral density (BMD) z-scores from Dual energy X-Ray absorptiometry (DEXA) have been reported in childhood HSCT survivors. However, BMD z-scores are unreliable in patients with short stature.Objective: To investigate the influence of HSCT/TBI on size-corrected BMD in childhood leukaemia survivors.Method: Post-pubertal leukaemia survivors (16–26 years) treated with HSCT/TBI (10–1...

Background: Adult survivors of childhood leukaemia treated with bone marrow transplantation and total body irradiation (BMT/TBI) have an increased risk of diabetes mellitus (DM) disproportionate to their level of adiposity or other recognised risk factors. Post prandial hyperglycaemia due to reduced β-cell reserve after irradiation will be missed by fasting glucose (FG) levels. However, the UK National Institute of Clinical Excellence (NICE) screening guidelines recommend...

Background: Adult survivors of childhood acute lymphoblastic leukaemia (ALL) treated with bone marrow transplantation (BMT) and total body irradiation (TBI) have increased risk of impaired glucose tolerance (IGT) and diabetes mellitus (DM). Insulin resistance (IR) has been described, but effects of TBI on pancreatic growth and β-cell function have not been previously reported.Method: Two groups of childhood ALL survivors were studied: Group 1, treat...

Introduction: This study explores the role of different fat depots in the aetiology of abnormal glucose homeostasis in childhood ALL survivors treated with BMT and TBI using detailed body composition assessments with MRI and DEXA scanning.Method: 52 (16–26 year old) childhood ALL survivors treated with (group 1, n=21, M=11) and without (group 2, n=31, M=13) BMT and TBI and 20 obese subjects (group 3, M=10) were inv...

Introduction: Measures commonly used to assess adiposity are often considered to reflect visceral adiposity and hence used as indicators of cardiovascular risk. This study compares common clinical adiposity measures with abdominal MRI, a direct measure of visceral fat, to assess if this relationship applies in patients with abnormal body composition.Method: Fifty childhood leukaemia survivors (16–26 years) treated with bone marrow transplantation/to...

Introduction: Childhood cancer survivors (CCS) are at risk of vitamin D (VitD) deficiency because of chronic ill health and advice to limit sunlight exposure. Studies have demonstrated associations between VitD deficiency and cardiovascular disease. Some CCS has increased risk of cardiovascular morbidity, but data on VitD status are limited.Aim: To evaluate VitD status in CCS.Method: We compared VitD levels in CCS (n=83 (M=4...